We are excited to announce a new collaboration with the Center for Biomarker Research in Medicine (CBMed) in Graz, Austria! This validation study aims to evaluate a sustainable alternative to deep-freezing for plasma preservation.
Plasma is a complex biological fluid with high clinical relevance, but it is particularly sensitive to freeze-thaw cycles and storage conditions. The extensive use of ultra-low temperature (ULT) freezers is increasingly incompatible with growing demands related to costs, energy consumption, space, and safety in biological sample collections.
Study Objective:
To compare the quality and functionality of plasma samples stabilized and stored at room temperature using 300K Solutions’ technology versus those frozen at -80°C, within the context of a prospective sample collection. The study will evaluate different plasma/serum metabolites to demonstrate the usefulness of lyophilized samples.
Materials and Methods:
The study will use 20 plasma and serum samples (10 from cirrhosis patients and 10 from healthy volunteers). Each sample will be divided into aliquots: four will undergo lyophilization and four will be stored at -80°C as controls. Quality assessment will be performed at three different timepoints: after 1, 6, and 12 months of storage, using ELISA and routine biochemistry parameters.
We look forward to sharing the results of this important validation study!
