Stabilization of Cell lines as Reference material: what other specific use cases could you envision for it?

PabloP. — Mon, 22 Jun 2026 12:18:52 +0000

In many cases, it is advisable—or even necessary—to include positive controls in our NGS reactions to ensure that the specific mutations or gene rearrangements we detect are not artefacts.

To achieve this, it is necessary to continuously maintain different cell lines carrying defined mutations in culture, which are then processed as any other sample during the sample preparation workflow.

This approach provides a high degree of robustness and confidence in the assay. However, it has a significant limitation: it requires continuous cell culture maintenance, with the additional impact that repeated passaging can have on cell quality.

Through the stabilization of specific cell lines using the technology developed by 300K, we can eliminate the need for continuous cell culture maintenance, allowing samples to be stored at room temperature and used whenever required increasing lab efficiency.

Liquid biopsy using dried plasma samples: would this work in your workflow?

300K Team — Tue, 07 Apr 2026 11:14:31 +0000

Liquid biopsy has opened the door to diagnosing and monitoring solid tumors using liquid samples instead of traditional tissue biopsies. In these workflows, circulating DNA (ctDNA/cfDNA) extracted from plasma is typically analyzed using techniques such as digital PCR or NGS. The advantages over invasive tissue biopsies are well known: lower risk, repeatability, and easier patient follow‑up. However, one of the main limitations in real workflows is still pre‑analytical handling: sample stability, logistics, and standardization often become bottlenecks.

With 300K’s plasma stabilization technology, circulating DNA can be preserved with purity and integrity comparable to frozen samples, without relying on cold‑chain conditions.

If you work with liquid biopsy, how would this fit into your day‑to‑day practice? Would freeze-dried plasma samples work in your current workflow?

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Stabilization of Cell lines as Reference material: what other specific use cases could you envision for it?

Liquid biopsy using dried plasma samples: would this work in your workflow?